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The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.

Organizational records of the nonprofit Human Service Employees Registration and Voter Education Fund (Human SERVE), which advocated for Americans to have the opportunity to register to vote at government-run social services agencies. The collection includes records of Human SERVE's funding sources, organizational partnerships, and campaigns. There are also records of Human SERVE's involvement in the passage and implementation of laws on both the state and federal levels that resulted from the organization's advocacy work. The bulk of the state-level records are from New York State. Finally, there are internal records related to the organization's staffing, Board, and legal compliance.

This collection primarily contains materials related to Percy and Harold Uris and their real estate businesses. Correspondence, financial records, and estate papers document the professional and personal lives of the brothers and their wives. The bulk of the business records are from their properties at 380 Madison Avenue and 300 Park Avenue. There is limited information about the other Uris properties and Uris Building Corporation. Finally, the collection contains records from the Uris Brothers Foundation, Inc about the family's philanthropic endeavors.