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The records include addresses, annual reports, correspondence, memos, minutes, program files, newsclippings, administrative records, photographs, video tape, and film. They include material dating from the decades prior to the establishment of the settlement which shed light on the philosophy and motivation of its founders, and offer a unique view of the first wave of the settlement house movement in America. The records document social conditions, demographic change, political activity and philanthropy in New York City. Addresses by East Side House founder Everett P. Wheeler, included in Series I, document his family history and career as a lawyer and civic reformer prior to the founding of East Side House. Wheeler's correspondence details his role in establishing the settlement and managing it during its first decades.

The records include annual reports, board minutes, budgets, by-laws, correspondence, memos, publications, reports, scrapbooks, photographs and printed material. They document the settlement and its antecedent institutions from 1854 to 1994, offering a unique view of the first wave of the settlement house movement in America, as well as related philanthropy and social welfare activities in New York City over a 140 year period. The origins of Goddard-Riverside Community Center are documented in Series I, which includes eight institutional subseries. These records provide a wealth of information on philanthropic, social welfare and settlement work from the mid-19th century through the 1950s. Series II - IV document the activities of the settlement from 1959 to the 1990s, with a particular emphasis on the urban renewal period of the 1960s. Items in Series VII include photographs of staff, activities, facilities of Goddard-Riverside Community Center, as well as several of its predecessor institutions.

Correspondence, manuscripts, lectures, notes, diaries, notebooks, reports, financial records, blueprints, photographs, and printed materials of Y.C. James Yen and the IIRR concerned with the development, sharing, and financing innovative methods of teaching, improving agriculture, health and family planning, and education in impoverished villages. Among the cataloged correspondents are: Pearl Buck, William O. Douglas, Nelson Rockefeller, and DeWitt Clinton.

These files concern the publication of Anne Frank: the Diary of a Young Girl in 1952, the dramatization of this diary and the subsequent legal disputes with Meyer Levin over the play, and the motion picture made from the play. They also deal with the activities of the Anne Frank Foundation, primarily support for the renovation of the Anne Frank House in Amsterdam and the programs of the International Anne Frank Youth Center. These files include 145 letters from her father, Otto Frank, and letters from Alfred Kazin, Max Lerner, Meyer Levin, and Eleanor Roosevelt. There are also seven letters from Adela Rogers St. Johns and related materials about her own books and the 1963 volume of minutes of the Doubleday & Co. Publishing Committee.

The LaGuardia Memorial House Records document the settlement's activities from its earliest years as "The Home Garden" to its current social service programs for the youth of East Harlem. They offer a unique view of the first wave of the settlement movement in America, and document social conditions, demographic change, political activity, philanthropy and social work in East Harlem over a 90 year period. The records include: annual reports, board minutes and correspondence, headworker correspondence, financial records, fundraising information, and photographs.

The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.