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The records include addresses, annual reports, correspondence, memos, minutes, program files, newsclippings, administrative records, photographs, video tape, and film. They include material dating from the decades prior to the establishment of the settlement which shed light on the philosophy and motivation of its founders, and offer a unique view of the first wave of the settlement house movement in America. The records document social conditions, demographic change, political activity and philanthropy in New York City. Addresses by East Side House founder Everett P. Wheeler, included in Series I, document his family history and career as a lawyer and civic reformer prior to the founding of East Side House. Wheeler's correspondence details his role in establishing the settlement and managing it during its first decades.

This collection includes nine letters of Ralph Waldo Emerson as well as letters of Louis Agassiz, Amos Bronson Alcott, Oliver Wendell Holmes, Sr., Henry Wadsworth Longfellow, James Russell Lowell, John Lothrop Motley, Charles Sumner, and John Greenleaf Whittier. In addition, there are two incomplete manuscripts by Emerson and one document from the Liverpool Custom-house signed by Nathaniel Hawthorne as Consul for the United States. The collection also includes the corrected typescript, index, and page and galley proofs for Thomas Franklin Currier, A BIBLIOGRAPHY OF OLIVER WENDELL HOLMES (New York, 1953) which was edited by Professor Tilton. Also, some early correspondence and photographs of the Tilton family and friends. There are letters from the actors Annie Louise Ames, Richard J. Dillon, and Hans L. Meery to Tilton's grandfather, Bernard Paul Verne, as well as photographs, tintypes, and daguerreotypes of the Verne family and friends.

Correspondence, manuscripts, notes, drafts of speeches, appointment books, subject files, documents, photographs, memorabilia and printed materials. There are notes from her lectures on Sociology at Adelphi College in 1911-1912; papers from 1912-1932, when Perkins served on the Commission for Safety and on the Industrial Commission of New York State; the main body of the material is from the period of her cabinet office, 1933-1945; and some items from her days on the Civil Service Commission, 1946-1953. Also included are personal and family papers.