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Central Files is composed chiefly of correspondence sent and received between Columbia University administrators and other University officers, faculty, and trustees, as well as correspondence sent and received between University administrators and individuals and organizations from outside the university.

The surviving files of official correspondence, reports, documents, and printed materials of King's College from 1750 to 1784 and Columbia College from 1785 to 1890, as well as Columbia University up to 1964. The King's College era materials include grants, deeds, indentures, lists of governors, leases, accounts, etc. The Columbia College era papers commence with documentation regarding the attempts to revive the college at the end of the American Revolution. In the later period these papers primarily supplement and document the minutes of the meetings of the Board of Governors and the Board of Trustees. Much material was destroyed and scattered in the late 19th century leaving this collection quite incomplete.

This collection contains the speeches of Seth Low. The material within the collection spans from 1878 to 1916 and contains Low's opinions on political (with an emphasis on municipal government), collegiate, and religious matters.