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The materials that comprise the Historical Biographical Files have been collected and added to from a variety of sources over the years by current and previous staff. The files consist of materials related to people who have a connection to the University whether as student, alumni, administrator, faculty, staff, guest lecturer, or honorary degree recipient. Materials generally consist of newspaper and magazine clippings, press releases, programs, ephemera, printed matter, lists, reports, and pamphlets.

This collection contains photocopies of the Columbia College, and later Columbia University, President's annual reports from 1865-1881 and 1887-1948. The reports include fact and figures (enrollment, degrees conferred, tuition, expenses, gifts, etc.) and topical discussions (co-education, new degree programs, higher education and liberal arts education, current events, etc.).