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As the chair of psychiatry at Stanford University School of Medicine David Hamburg helped to found The Program in Human Biology. The series contains correspondence, notes, and typescripts relating to establishing the original Stanford University curriculum on human biology, and relating to a later Human Biology Middle Grades Curriculum Project, an attempt at adaptation of the SU Human Biology program to the middle school level. The Human Biology Middle Grades Curriculum Project also contains materials and writings on Puberty and Adolescence.

Third-party typescript materials and various printed matter, frequently underlined or with Dr. Hamburg's notes, and used as a basis of his later works. The majority of files are related to Hamburg's activities as a member of Stanford faculty and administration, however the series also contains background materials on primate research, human biology and adolescence, and background materials received by Hamburg as a Board of Trustees member.

The series consists of correspondence, memoranda, notes, drafts, teaching materials, typescripts, students' projects and dissertations, and research materials, documenting Hamburg's teaching and administrative career at Stanford's Center for Advanced Study in the Behavioral Sciences, serving as Reed-Hodgson Professor of Human Biology, and as chair of psychiatry at Stanford University School of Medicine. At the School of Medicine Hamburg established a new department of psychiatry and behavioral sciences, distinguished by its breadth of research on behavioral biology, especially in relation to mental illness. The series also documents his collaboration with Dr. Jonas Salk, participation in NIMH Research Task Force, and work on IOM program committee ( not to be confused with Hamburg's later IOM tenure)