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In the first session, Pagan discusses his initial involvement with Phoenix House and his role in founding the program. He explains how he joined Efrén Ramirez's rehabilitation program after years of chronic drug abuse and details how that initial program grew in membership and gradually evolved into Phoenix House. Pagan credits the creation of Phoenix House to the support group of six founding members that he maintained, and a move from Hart Island to Manhattan, which put the group out on their own. In the second session, Pagan discusses the dynamic that existed between the original six members of Phoenix House, as well as his childhood upbringing in Williamsburg as a young Puerto Rican immigrant. Pagan details the beginning of his drug use in the mid-1950s, due to his gang involvement and his subsequent bouts with incarceration. He explains how he joined Efrén Ramirez's program to rehabilitate and how he met the first few members of the Phoenix House program there. He then documents the acquisition of the first house and subsequent expansion.

In the first session, Mothner describes his career in magazine journalism, and, subsequently, in speechwriting for the Mayor of New York. He explains his prior connection to therapeutic communities, which led to his involvement with Phoenix House. He describes the process of writing the book Drugs, Parents and Children (1972) with Mitchell Rosenthal. He details the early therapeutic community methods, including tactics of humiliation. He speaks to his personal connection to addiction. Mothner describes his role in fundraising and crafting the Phoenix House narrative. He discusses the "academy model of treatment." Finally, Mothner comments on methadone versus therapeutic treatment for addiction, and recent marijuana legalization battles. In the second session, Mothner speaks on substance abuse among adolescents today. He discusses Phoenix House's changing treatment model, especially the role of adolescents in its evolution. He comments on the social aspects of working at Phoenix House, particularly his working relationship with Mitchell Rosenthal. He also comments on the Abraham Beame investigation and the plans for the Nancy Reagan Center in California. Finally, Mothner describes some of the major fundraising galas at Phoenix House.

Latson describes growing up in Raccoon Bend, Texas, and his relationship with his family. He narrates his experience in the US Army during the Korean War, with particular attention to the racism he encountered there. He discusses his introduction to Synanon while living in Los Angeles as an addict, and his education in that environment. He also mentions his involvement with the Nation of Islam. Latson describes various stages of his spiritual awakening. Finally, he tells of his introduction to Mitchell Rosenthal and Phoenix House.

In the first session, Singer discusses her career prior to Phoenix House, which included working in a halfway house, the District Attorney's office, victims' services, the Governor's Office on Criminal Justice and Alternatives to Incarceration, and a private foundation that generated materials for judges hearing substance abuse cases. She shares her own philosophy on substance abuse treatment, discussing both therapeutic community methods and methadone. She also describes her impressions of the relationship between union politics, racial politics, and city politics during a brief stint with the New York City Department of Corrections.

Ronald Williams narrates his early life in a West Indian neighborhood in Harlem and his pathway to substance abuse, incarceration, and, eventually the Morris Bernstein Institute. He describes leaving the Institute with a group of addicts to found Phoenix House. He gives particular attention to the therapeutic community method as it was conceived during Phoenix House's initial stages, and its predecessors. Williams also speaks on Phoenix House's importing of Synanon personnel, and that strategy's effect on the organization.

Howard Josepher narrates his experience as a drug addict sent to Odyssey House on a court mandate. During his time at Odyssey House, the organization split, and Josepher and a group of other addicts ended up at Phoenix House as some of the first residents. Josepher recounts his time at Phoenix House in light of his past experiences of different detox programs. He describes his troubles with the legal system while hiding from American authorities in Britain. After graduating from the Phoenix House program, Josepher becomes regional director at Phoenix House. He then talks about graduating from Hunter College Silberman School of Social Work, and the formation of his private practice, which he still operates today. Josepher also discusses his quest for a greater purpose and his attempts to find it through a discipleship in India. Josepher moves on to his work during the AIDS epidemic in the 1980s and how his experiences at Phoenix House influenced that work. Finally, Josepher discusses the methodology of abstinence-based rehabilitation programs and touches upon current debates surrounding drug treatment.

Bennetts chronicles her experience profiling Mitchell Rosenthal for Vanity Fair. She also discusses Nancy Reagan's reneging on the Lake View facility, and her involvement with "the drug issue" more generally. The interview is peppered with details about being a female journalist during the 1970s-1980s.

Fagin discusses her tenure as Mitchell Rosenthal's executive assistant and her subsequent role in fundraising and development. She narrates her own avenues to understanding addiction. She talks about moving to Hazelden, comparing its environment with Phoenix House's and assessing the translation of her skills from a nonprofit to a for-profit setting. Finally, she reflects on the state of the therapeutic community method given increased state regulations.

Peterson and Ganz Cooney discuss their philanthropic life histories, which include fiscal policy reform, and youth education and digital learning, respectively. They then discuss their friendship with Mitchell Rosenthal. They speak to their role in supporting Phoenix House through fundraising efforts via their own donations, connecting the organization to a number of influential donors, and encouraging innovative fundraising strategies that catapulted Phoenix House into the world of the New York elite.