- Central Files (Office of the President records), 1890-19841
- Chicanx Caucus Records, 2001-20141
- China Institute in America records, 1926-2012, bulk 1931-19961
- Citizens Union of the City of New York records, 1892-20201
- College of Pharmaceutical Sciences records, 1892-1976, bulk 1950-19761
- Columbia College papers, 1703-1964, bulk 1754-19201
- Columbia College records, 1875-2022, bulk 1969-19871
- Columbia LGBT records, 1961-1990, bulk 1967-19891
- Columbia University Committee on Student Organizations records, 1905-19191
- Columbia University Libraries Staff Association records, 1948-19501
- Columbia University Library Office files, 1890-19981
- Columbia University Press records, 1893-2000s, bulk 1923-2000s1
- Columbia University Senate Records, 1968-20081
- Columbia University in World War II collection, 1933-19751
- Columbia University. School of Library Service. Alumni collection, 1887-19671
- Comics Magazine Association of America records, 1974-19941
- Committee for Health in Southern Africa records, 1981-1998, bulk 1985-19911
- Community Service Society records, 1842-19951
- Constance Baker Motley Papers, 1935-20061
- Council for Research in the Humanities Records, 1926-1968, bulk 1926-1936; 1966-19681