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The collection consists of speeches, reports, publications, research notes, and correspondence. The bulk of the collection relates to Wu's involvement in the American Physical Society as well as her research activities. The correspondence is chiefly professional, relating to C. S. Wu's physics research, professional commitments, appointments, meetings, conferences, and publications. Correspondence also includes letters from individuals around the world praising Wu for her accomplishments, asking advice, arranging speaking engagements, discussing administrative matters, and trading research notes, as well as information on publications and other topics. In addition, the collection contains information on Wu's involvement in the development of an affirmative action program at Columbia University in the 1970's.

Correspondence, manuscripts, lectures, notes, diaries, notebooks, reports, financial records, blueprints, photographs, and printed materials of Y.C. James Yen and the IIRR concerned with the development, sharing, and financing innovative methods of teaching, improving agriculture, health and family planning, and education in impoverished villages. Among the cataloged correspondents are: Pearl Buck, William O. Douglas, Nelson Rockefeller, and DeWitt Clinton.

Notes and transcripts of articles, some in Chinese periodicals, health reports, etc. relating to medicine in China, to Chinese beliefs on health and medical matters, and to folk legends and beliefs in Chinese and Japanese culture. Included also are a group of printed pamphlets and articles on medicine.

The Ephemera collection on Chinese science, technology, law, and society (中国科技法律社会汇集) contains over 800 items published in China, dating from circa 1906 to 2010, with its bulk dating from 1931 to 1981. Materials include pamphlets, handbooks, picture books, posters, lantern slides, literacy flash cards, etc. The subject areas of the materials include science, technology, agriculture, personal hygiene, economy, culture, law, society, and politics, etc. The collection also includes works that reflected social, political, industrial transformation in China.

The Hanhun Li and Chu Fang Wu papers consist of diaries, writings, publications and incoming correspondence of Hanhun Li and his wife Chu Fang Wu, dating from 1926 to 1998.